Heterogeneity of T-cell receptor alpha-chain complementarity-determining region 3 in myelin basic protein-specific T cells increases with severity of multiple sclerosis.

The pathogenesis of multiple sclerosis (MS) is thought to involve a T-cell-mediated autoimmune process. Experimental allergic encephalomyelitis (EAE), an animal model resembling MS, can be induced by immunization with myelin antigens such as myelin basic protein. The T-cell antigen receptor (TCR) us...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Utz, U, Brooks, J A, McFarland, H F, Martin, R, Biddison, W E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44037/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7515505/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.12.5567
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