Identification of PB2 Mutations Responsible for the Efficient Replication of H5N1 Influenza Viruses in Human Lung Epithelial Cells

Highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry worldwide, resulting in sporadic infections in humans with approximately 60% mortality. However, efficient transmission of H5N1 viruses among humans has yet to occur, suggesting that further adaptation of H5N1 viruses...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Yamaji, Reina, Yamada, Shinya, Le, Mai Q., Li, Chengjun, Chen, Hualan, Qurnianingsih, Ema, Nidom, Chairul A., Ito, Mutsumi, Sakai-Tagawa, Yuko, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403392/
https://ncbi.nlm.nih.gov/pubmed/25609813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03328-14
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