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The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous in these bacteria greatly contribute to antibiotic resistance and present a major challenge for antibiotic development. M...

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Detalhes bibliográficos
Publicado no:Clin Microbiol Rev
Main Authors: Li, Xian-Zhi, Plésiat, Patrick, Nikaido, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402952/
https://ncbi.nlm.nih.gov/pubmed/25788514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CMR.00117-14
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