HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53

BACKGROUND: Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognostic factors in head and neck squamous cell carcinoma, but their role in squamous cell carcinoma of the anal canal (SCCAC) is less well established. The objective of this study was to determine the prognostic...

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Vydáno v:Br J Cancer
Hlavní autoři: Meulendijks, D, Tomasoa, N B, Dewit, L, Smits, P H M, Bakker, R, van Velthuysen, M-L F, Rosenberg, E H, Beijnen, J H, Schellens, J H M, Cats, A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402454/
https://ncbi.nlm.nih.gov/pubmed/25871546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.20
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