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Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

The NADPH oxidase of neutrophils, essential for innate immunity, passes electrons across the phagocytic membrane to form superoxide in the phagocytic vacuole. Activity of the oxidase requires that charge movements across the vacuolar membrane are balanced. Using the pH indicator SNARF, we measured c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Levine, Adam P., Duchen, Michael R., de Villiers, Simon, Rich, Peter R., Segal, Anthony W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401748/
https://ncbi.nlm.nih.gov/pubmed/25885273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125906
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