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CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in COPD CD8 cells

BACKGROUND: There are increased numbers of pulmonary CD8 lymphocytes in COPD. Calcium-release activation calcium (CRAC) channels play a central role in lymphocyte activation though the regulation of the transcription factor nuclear factor of activated T cells (NFAT). OBJECTIVE: We studied the expres...

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Dettagli Bibliografici
Pubblicato in:Clin Sci (Lond)
Autori principali: Grundy, Seamus, Kaur, Manminder, Plumb, Jonathan, Reynolds, Sophie, Hall, Simon, House, David, Begg, Malcolm, Ray, David, Singh, Dave
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401013/
https://ncbi.nlm.nih.gov/pubmed/23905758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20130152
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