Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin

Sec1/Munc18 (SM) proteins are essential for membrane trafficking, but their molecular mechanism remains unclear. Using a single vesicle-vesicle content-mixing assay with reconstituted neuronal SNAREs, synaptotagmin-1, and complexin-1, we show that the neuronal SM protein Munc18a/nSec1 has no effect...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Zhang, Yunxiang, Diao, Jiajie, Colbert, Karen N., Lai, Ying, Pfuetzner, Richard A., Padolina, Mark S., Vivona, Sandro, Ressl, Susanne, Cipriano, Daniel J., Choi, Ucheor B., Shah, Niket, Weis, William I., Brunger, Axel T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
Onderwerpen:
Neurobiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400359/
https://ncbi.nlm.nih.gov/pubmed/25716318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630772
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