The Pivotal Role of the Mitochondrial Amidoxime Reducing Component 2 in Protecting Human Cells against Apoptotic Effects of the Base Analog N(6)-Hydroxylaminopurine

N-Hydroxylated nucleobases and nucleosides as N-hydroxylaminopurine (HAP) or N-hydroxyadenosine (HAPR) may be generated endogenously in the course of cell metabolism by cytochrome P450, by oxidative stress or by a deviating nucleotide biosynthesis. These compounds have shown to be toxic and mutageni...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Plitzko, Birte, Havemeyer, Antje, Kunze, Thomas, Clement, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400328/
https://ncbi.nlm.nih.gov/pubmed/25713076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.640052
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