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The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila

Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shaping the response of the evolutionary conserved Jak-Stat pathwa...

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Vydáno v:PLoS Pathog
Hlavní autoři: Merkling, Sarah H., Bronkhorst, Alfred W., Kramer, Jamie M., Overheul, Gijs J., Schenck, Annette, Van Rij, Ronald P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399909/
https://ncbi.nlm.nih.gov/pubmed/25880195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004692
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