Lymphocyte Gene Expression Signatures from Patients and Mouse Models of Hereditary Hemochromatosis Reveal a Function of HFE as a Negative Regulator of CD8(+) T-Lymphocyte Activation and Differentiation In Vivo

Abnormally low CD8(+) T-lymphocyte numbers is characteristic of some patients with hereditary hemochromatosis (HH), a MHC-linked disorder of iron overload. Both environmental and genetic components are known to influence CD8(+) T-lymphocyte homeostasis but the role of the HH associated protein HFE i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Costa, Mónica, Cruz, Eugénia, Oliveira, Susana, Benes, Vladimir, Ivacevic, Tomi, Silva, Maria João, Vieira, Inês, Dias, Francisco, Fonseca, Sónia, Gonçalves, Marta, Lima, Margarida, Leitão, Catarina, Muckenthaler, Martina U., Pinto, Jorge, Porto, Graça
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399836/
https://ncbi.nlm.nih.gov/pubmed/25880808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124246
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