Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer

BACKGROUND: AF-6/afadin plays an important role in the formation of adherence junctions. In breast and colon cancer, loss of AF-6/afadin induces cell migration and cell invasion. We aimed to elucidate the role of AF-6/afadin in human endometrial cancer. METHODS: Morphology and AF-6/afadin expression...

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Publicat a:BMC Cancer
Autors principals: Yamamoto, Takuro, Mori, Taisuke, Sawada, Morio, Matsushima, Hiroshi, Ito, Fumitake, Akiyama, Makoto, Kitawaki, Jo
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399104/
https://ncbi.nlm.nih.gov/pubmed/25879875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1286-x
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