Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxide

Autophagy is one of the major causes of drug resistance. For example, the angiogenesis inhibitor bevacizumab shows only transient and short-term therapeutic effects, whereas long-term therapeutic benefits are rarely observed, probably due to hypoxia-induced autophagy. Nitric oxide (NO) is an importa...

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Bibliografiske detaljer
Udgivet i:Cancer Sci
Main Authors: Ishima, Yu, Inoue, Aki, Fang, Jun, Kinoshita, Ryo, Ikeda, Mayumi, Watanabe, Hiroshi, Maeda, Hiroshi, Otagiri, Masaki, Maruyama, Toru
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2015
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399024/
https://ncbi.nlm.nih.gov/pubmed/25457681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12577
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