Combined Loss of the GATA4 and GATA6 Transcription Factors in Male Mice Disrupts Testicular Development and Confers Adrenal-Like Function in the Testes

The roles of the GATA4 and GATA6 transcription factors in testis development were examined by simultaneously ablating Gata4 and Gata6 with Sf1Cre (Nr5a1Cre). The deletion of both genes resulted in a striking testicular phenotype. Embryonic Sf1Cre; Gata4(flox/flox) Gata6(flox/flox) (conditional doubl...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Padua, Maria B., Jiang, Tianyu, Morse, Deborah A., Fox, Shawna C., Hatch, Heather M., Tevosian, Sergei G.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398756/
https://ncbi.nlm.nih.gov/pubmed/25668066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1907
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