Fluorescence microscopy colocalization of lipid-nucleic acid nanoparticles with wildtype and mutant Rab5-GFP: A platform for investigating early endosomal events

Endosomal entrapment is known to be a major bottleneck to successful cytoplasmic delivery of nucleic acids (NAs) using cationic liposome-NA nanoparticles (NPs). Quantitative measurements of distributions of NPs within early endosomes (EEs) have proven difficult due to the sub-resolution size and sho...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Majzoub, Ramsey N., Chan, Chia-Ling, Ewert, Kai K., Silva, Bruno F. B., Liang, Keng S., Safinya, Cyrus R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398653/
https://ncbi.nlm.nih.gov/pubmed/25753113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2015.03.001
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