THE HIGH GRADE (WHO G3) PANCREATIC NEUROENDOCRINE TUMOR CATEGORY IS MORPHOLOGICALLY AND BIOLOGICALLY HETEROGENEOUS AND INCLUDES BOTH WELL DIFFERENTIATED AND POORLY DIFFERENTIATED NEOPLASMS

BACKGROUND: The 2010 WHO classification recommends that pancreatic neuroendocrine tumors should be graded based on mitotic rate and Ki67 index, with grade 2 (G2) pancreatic neuroendocrine tumor (PanNET) defined as having a mitotic rate of 2–20 mitotic figures/10 high power fields (HPF) or a Ki67 ind...

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Pubblicato in:Am J Surg Pathol
Autori principali: Basturk, Olca, Yang, Zhaohai, Tang, Laura H., Hruban, Ralph H., Adsay, N. Volkan, McCall, Chad M., Krasinskas, Alyssa M., Jang, Kee-Taek, Frankel, Wendy L., Balci, Serdar, Sigel, Carlie, Klimstra, David S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398606/
https://ncbi.nlm.nih.gov/pubmed/25723112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0000000000000408
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