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Formalin Evokes Calcium Transients from the Endoplasmatic Reticulum

The formalin test is the most widely used behavioral screening test for analgesic compounds. The cellular mechanism of action of formaldehyde, inducing a typically biphasic pain-related behavior in rodents is addressed in this study. The chemoreceptor channel TRPA1 was suggested as primary transduce...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fischer, Michael J. M., Soller, Kailey J., Sauer, Susanne K., Kalucka, Joanna, Veglia, Gianluigi, Reeh, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398422/
https://ncbi.nlm.nih.gov/pubmed/25875358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123762
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