Neofunctionalization of the Sec1 α1,2fucosyltransferase Paralogue in Leporids Contributes to Glycan Polymorphism and Resistance to Rabbit Hemorrhagic Disease Virus

RHDV (rabbit hemorrhagic disease virus), a virulent calicivirus, causes high mortalities in European rabbit populations (Oryctolagus cuniculus). It uses α1,2fucosylated glycans, histo-blood group antigens (HBGAs), as attachment factors, with their absence or low expression generating resistance to t...

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Udgivet i:PLoS Pathog
Main Authors: Nyström, Kristina, Abrantes, Joana, Lopes, Ana Margarida, Le Moullac-Vaidye, Béatrice, Marchandeau, Stéphane, Rocher, Jézabel, Ruvoën-Clouet, Nathalie, Esteves, Pedro J., Le Pendu, Jacques
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398370/
https://ncbi.nlm.nih.gov/pubmed/25875017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004759
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