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Activation of Pheromone-Sensitive Neurons Is Mediated by Conformational Activation of Pheromone-Binding Protein

Detection of volatile odorants by olfactory neurons is thought to result from direct activation of seven-transmembrane odorant receptors by odor molecules. Here, we show that detection of the Drosophila pheromone, 11-cis vaccenyl acetate (cVA), is instead mediated by pheromone-induced conformational...

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Pubblicato in:Cell
Autori principali: Laughlin, John D., Ha, Tal Soo, Jones, David N. M., Smith, Dean P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397981/
https://ncbi.nlm.nih.gov/pubmed/18585358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.04.046
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