Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α(+)thalassemia

BACKGROUND: Individually, the red blood cell (RBC) polymorphisms sickle cell trait (HbAS) and α(+)thalassemia protect against severe Plasmodium falciparum malaria. It has been shown through epidemiological studies that the co-inheritance of both conditions results in a loss of the protection afforde...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Herbert Opi, D., Ochola, Lucy B., Tendwa, Metrine, Siddondo, Bethsheba R., Ocholla, Harold, Fanjo, Harry, Ghumra, Ashfaq, Ferguson, David J.P., Alexandra Rowe, J., Williams, Thomas N.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397954/
https://ncbi.nlm.nih.gov/pubmed/25893206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2014.10.006
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