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Neonatal Diabetes and Congenital Hyperinsulinism Caused by Mutations in ABCC8/SUR1 are Associated with Altered and Opposite Affinities for ATP and ADP
ATP-sensitive K(+) (K(ATP)) channels composed of potassium inward-rectifier type 6.2 and sulfonylurea receptor type 1 subunits (Kir6.2/SUR1)(4) are expressed in various cells in the brain and endocrine pancreas where they couple metabolic status to membrane potential. In β-cells, increases in cytoso...
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| Publicado no: | Front Endocrinol (Lausanne) |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4397924/ https://ncbi.nlm.nih.gov/pubmed/25926814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2015.00048 |
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