Dexmedetomidine ameliorates nocifensive behavior in humanized sickle cell mice

Patients with sickle cell disease (SCD) can have recurrent episodes of vaso-occlusive crises, which are associated with severe pain. While opioids are the mainstay of analgesic therapy, in some patients, increasing opioid use results in continued and increasing pain. Many believe that this phenomeno...

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Veröffentlicht in:Eur J Pharmacol
Hauptverfasser: Calhoun, Gabriela, Wang, Li, Almeida, Luis E.F., Kenyon, Nicholas, Afsar, Nina, Nouraie, Mehdi, Finkel, Julia C., Quezado, Zenaide M.N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397100/
https://ncbi.nlm.nih.gov/pubmed/25724786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2015.02.027
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