Culture Adaptation Alters Transcriptional Hierarchies among Single Human Embryonic Stem Cells Reflecting Altered Patterns of Differentiation

We have used single cell transcriptome analysis to re-examine the substates of early passage, karyotypically Normal, and late passage, karyotypically Abnormal (‘Culture Adapted’) human embryonic stem cells characterized by differential expression of the cell surface marker antigen, SSEA3. The result...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gokhale, Paul J., Au-Young, Janice K., Dadi, SriVidya, Keys, David N., Harrison, Neil J., Jones, Mark, Soneji, Shamit, Enver, Tariq, Sherlock, Jon K., Andrews, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397016/
https://ncbi.nlm.nih.gov/pubmed/25875838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123467
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