Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications

In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. On the o...

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Bibliographic Details
Published in:Mediators Inflamm
Main Authors: Alunno, Alessia, Manetti, Mirko, Caterbi, Sara, Ibba-Manneschi, Lidia, Bistoni, Onelia, Bartoloni, Elena, Valentini, Valentina, Terenzi, Riccardo, Gerli, Roberto
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2015
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397010/
https://ncbi.nlm.nih.gov/pubmed/25918479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/751793
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