Učitavanje...
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
Metabolic reprogramming is implicated in macrophage activation, but the underlying mechanisms are poorly understood. Here, we demonstrate that the NOTCH1 pathway dictates activation of M1 phenotypes in isolated mouse hepatic macrophages (HMacs) and in a murine macrophage cell line by coupling transc...
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| Izdano u: | J Clin Invest |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4396469/ https://ncbi.nlm.nih.gov/pubmed/25798621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76468 |
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