IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age

Decline in immune function and inflammation concomitantly develop with ageing. Here we focus on the impact of this inflammatory environment on T cells, and demonstrate that in contrast to successful tumour elimination in young mice, replenishment of tumour-specific CD4(+) T cells fails to induce tum...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Tsukamoto, Hirotake, Senju, Satoru, Matsumura, Keiko, Swain, Susan L., Nishimura, Yasuharu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396369/
https://ncbi.nlm.nih.gov/pubmed/25850032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7702
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker