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Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I)

Isoflavonoids have been shown to inhibit tumor proliferation and metastasis by activating cell death pathways. As such, they have been widely studied as potential therapies for cancer prevention. The second generation synthetic isoflavan analogues ME-143 and ME-344 also exhibit anti-cancer effects,...

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Bibliografiska uppgifter
I publikationen:Am J Cancer Res
Huvudupphovsmän: Lim, Sze Chern, Carey, Kirstyn T, McKenzie, Matthew
Materialtyp: Artigo
Språk:Inglês
Publicerad: e-Century Publishing Corporation 2015
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396027/
https://ncbi.nlm.nih.gov/pubmed/25973307
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