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The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling
The c-Jun/AP-1 transcription factor controls key cellular behaviours, including proliferation and apoptosis, in response to JNK and Ras/MAPK signalling. While the JNK pathway has been well characterised, the mechanism of activation by Ras was elusive. Here we identify the uncharacterised ubiquitin l...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4395875/ https://ncbi.nlm.nih.gov/pubmed/25851810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7782 |
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