Cell Cycle Status of CD34(+) Hemopoietic Stem Cells Determines Lentiviral Integration in Actively Transcribed and Development-related Genes

Gene therapy utilizing lentiviral-vectors (LVs) is postulated as a dynamic therapeutic alternative for monogenic diseases. However, retroviral gene transfer may cause insertional mutagenesis. Although, such risks had been originally estimated as extremely low, several reports of leukemias or clonal...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Papanikolaou, Eleni, Paruzynski, Anna, Kasampalidis, Ioannis, Deichmann, Annette, Stamateris, Evangelos, Schmidt, Manfred, von Kalle, Christof, Anagnou, Nicholas P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395775/
https://ncbi.nlm.nih.gov/pubmed/25523760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.246
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