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Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a nuclear hormone receptor involved in regulating various metabolic and immune processes. The PPAR family of receptors possesses a large binding cavity that imparts promiscuity of ligand binding not common to other nuclear receptors. This f...
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| Veröffentlicht in: | J Comput Aided Mol Des |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4395532/ https://ncbi.nlm.nih.gov/pubmed/25616366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-015-9831-x |
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