Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

Mutations in SPAST, encoding spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). HSP is characterized by weakness and spasticity of the lower limbs, owing to progressive retrograde degeneration of the long corticospinal axons. Spastin is a conserved microtub...

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Bibliografski detalji
Izdano u:PLoS Genet
Glavni autori: Papadopoulos, Chrisovalantis, Orso, Genny, Mancuso, Giuseppe, Herholz, Marija, Gumeni, Sentiljana, Tadepalle, Nimesha, Jüngst, Christian, Tzschichholz, Anne, Schauss, Astrid, Höning, Stefan, Trifunovic, Aleksandra, Daga, Andrea, Rugarli, Elena I.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395272/
https://ncbi.nlm.nih.gov/pubmed/25875445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005149
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