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LRP5 deficiency down-regulates Wnt signalling and promotes aortic lipid infiltration in hypercholesterolaemic mice

Low-density lipoprotein receptor-related protein 5 (LRP5) is a member of the LDLR family that orchestrates cholesterol homoeostasis. The role of LRP5 and the canonical Wnt pathway in the vascular wall of dyslipidaemic animals remains unknown. In this study, we analysed the role of LRP5 and the Wnt s...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Borrell-Pagès, Maria, Romero, July Carolina, Badimon, Lina
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395191/
https://ncbi.nlm.nih.gov/pubmed/25656427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12396
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