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Heteroresistance to Colistin in Klebsiella pneumoniae Associated with Alterations in the PhoPQ Regulatory System

A multidrug-resistant Klebsiella pneumoniae isolate exhibiting heteroresistance to colistin was investigated. The colistin-resistant subpopulation harbored a single amino acid change (Asp191Tyr) in protein PhoP, which is part of the PhoPQ two-component system that activates pmrHFIJKLM expression res...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Jayol, Aurélie, Nordmann, Patrice, Brink, Adrian, Poirel, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394806/
https://ncbi.nlm.nih.gov/pubmed/25733503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05055-14
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