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The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells

Osteoporosis is an age-related progressive bone disease. Trp53 (p53) is not only a famous senescence marker but also a transcription regulator which played a critical role in osteogenesis. However, how p53 contributes to the bone mass loss in age-related osteoporosis is still unclear. Here, we found...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Liu, Wenjia, Qi, Meng, Konermann, Anna, Zhang, Liqiang, Jin, Fang, Jin, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394731/
https://ncbi.nlm.nih.gov/pubmed/25855145
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