Antagonist-Induced Conformational Changes in Dopamine Transporter Extracellular Loop Two Involve Residues in a Potential Salt Bridge

Ligand-induced changes in the conformation of extracellular loop (EL) 2 in the rat (r) dopamine transporter (DAT) were examined using limited proteolysis with endoproteinase Asp-N and detection of cleavage products by epitope-specific immunoblotting. The principle N-terminal fragment produced by Asp...

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Detalhes bibliográficos
Publicado no:Neurochem Int
Main Authors: Gaffaney, Jon D., Shetty, Madhur, Felts, Bruce, Pramod, Akula-Bala, Foster, James D., Henry, L. Keith, Vaughan, Roxanne A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394652/
https://ncbi.nlm.nih.gov/pubmed/24269640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2013.11.003
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