Wnt/β-Catenin signaling reduces Bacillus Calmette-Guerin-induced macrophage necrosis through a ROS -mediated PARP/AIF-dependent pathway

BACKGROUND: Necrosis of alveolar macrophages following Mycobacterium tuberculosis infection has been demonstrated to play a vital role in the pathogenesis of tuberculosis. Our previous study demonstrated that Wnt/β-catenin signaling was able to promote mycobacteria-infected cell apoptosis by a caspa...

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Gepubliceerd in:BMC Immunol
Hoofdauteurs: Wu, Xiaoling, Deng, Guangcun, Li, Min, Li, Yong, Ma, Chunyan, Wang, Yujiong, Liu, Xiaoming
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394565/
https://ncbi.nlm.nih.gov/pubmed/25887795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-015-0080-5
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