The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.
Many human tumors contain an activating mutation in one of the ras protooncogenes. Additionally, these tumor cells are often heteroploid and characterized by chromosome breaks and rearrangements that are consequences of the genomic instability that is thought to contribute to tumor progression. The...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43944/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8197195/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.11.5124 |
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