Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK)

With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. This effect is inhibited via phosphorylation at Ser1196 by serum/glucocorticoid-induced kinase 1 (SGK1), and this inhibi...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Lin, Dao-Hong, Yue, Peng, Yarborough, Orlando, Scholl, Ute I., Giebisch, Gerhard, Lifton, Richard P., Rinehart, Jesse, Wang, Wen-Hui
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394290/
https://ncbi.nlm.nih.gov/pubmed/25805816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503437112
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