Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK)

With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. This effect is inhibited via phosphorylation at Ser1196 by serum/glucocorticoid-induced kinase 1 (SGK1), and this inhibi...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Lin, Dao-Hong, Yue, Peng, Yarborough, Orlando, Scholl, Ute I., Giebisch, Gerhard, Lifton, Richard P., Rinehart, Jesse, Wang, Wen-Hui
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394290/
https://ncbi.nlm.nih.gov/pubmed/25805816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503437112
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