Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK)

With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. This effect is inhibited via phosphorylation at Ser1196 by serum/glucocorticoid-induced kinase 1 (SGK1), and this inhibi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Lin, Dao-Hong, Yue, Peng, Yarborough, Orlando, Scholl, Ute I., Giebisch, Gerhard, Lifton, Richard P., Rinehart, Jesse, Wang, Wen-Hui
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2015
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394290/
https://ncbi.nlm.nih.gov/pubmed/25805816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503437112
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