Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus

BACKGROUND: Oxytetracycline (OTC) is a broad-spectrum antibiotic commercially produced by Streptomyces rimosus. Despite its importance, little is known about the regulation of OTC biosynthesis, which hampered any effort to improve OTC production via engineering regulatory genes. RESULTS: A gene enco...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Microb Cell Fact
Main Authors: Yin, Shouliang, Wang, Weishan, Wang, Xuefeng, Zhu, Yaxin, Jia, Xiaole, Li, Shanshan, Yuan, Fang, Zhang, Yuxiu, Yang, Keqian
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393881/
https://ncbi.nlm.nih.gov/pubmed/25886456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0231-7
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