Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus

BACKGROUND: Oxytetracycline (OTC) is a broad-spectrum antibiotic commercially produced by Streptomyces rimosus. Despite its importance, little is known about the regulation of OTC biosynthesis, which hampered any effort to improve OTC production via engineering regulatory genes. RESULTS: A gene enco...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Yin, Shouliang, Wang, Weishan, Wang, Xuefeng, Zhu, Yaxin, Jia, Xiaole, Li, Shanshan, Yuan, Fang, Zhang, Yuxiu, Yang, Keqian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393881/
https://ncbi.nlm.nih.gov/pubmed/25886456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0231-7
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