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Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus

BACKGROUND: Oxytetracycline (OTC) is a broad-spectrum antibiotic commercially produced by Streptomyces rimosus. Despite its importance, little is known about the regulation of OTC biosynthesis, which hampered any effort to improve OTC production via engineering regulatory genes. RESULTS: A gene enco...

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التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Microb Cell Fact
المؤلفون الرئيسيون:	Yin, Shouliang, Wang, Weishan, Wang, Xuefeng, Zhu, Yaxin, Jia, Xiaole, Li, Shanshan, Yuan, Fang, Zhang, Yuxiu, Yang, Keqian
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	BioMed Central 2015
الموضوعات:	Research
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4393881/ https://ncbi.nlm.nih.gov/pubmed/25886456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0231-7
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus

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