Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue

BACKGROUND: Lactate dehydrogenase A (LDHA) and Pyruvate Kinase M2 (PKM2) are important enzymes of glycolysis. Both of them can be phosphorylated and therefore regulated by Fibroblast growth factor receptor 1 (FGFR1). While phosphorylation of LDHA at tyrosine10 leads to tetramerization and activation...

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Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Kachel, Paul, Trojanowicz, Bogusz, Sekulla, Carsten, Prenzel, Hanna, Dralle, Henning, Hoang-Vu, Cuong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393606/
https://ncbi.nlm.nih.gov/pubmed/25880801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1135-y
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