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Effect of acute acid-base disturbances on the phosphorylation of phospholipase C-γ1 and Erk1/2 in the renal proximal tubule

The renal proximal tubule (PT) plays a major role in whole-body pH homeostasis by secreting H(+) into the tubule lumen. Previous work demonstrated that PTs respond to basolateral changes in [CO(2)] and [[Image: see text]] by appropriately altering H(+) secretion—responses blocked by the ErbB inhibit...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Skelton, Lara A, Boron, Walter F
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393148/
https://ncbi.nlm.nih.gov/pubmed/25780091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12280
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