Mouse pharmacokinetics and metabolism of the curcumin analog, 4-Piperidione,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993)

PURPOSE: Curcumin, a keto-enol constituent of turmeric, has in vitro and in vivo antitumor activity. However, in vivo potency is low due to poor oral absorption. The mono-carbonyl analog, 3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone acetate (EF-24, NSC 716993), exhibited broad spectrum activity...

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Publicado en:Cancer Chemother Pharmacol
Main Authors: Reid, Joel M., Buhrow, Sarah A., Gilbert, Judith A., Jia, Lee, Shoji, Mamoru, Snyder, James P., Ames, Matthew M.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392893/
https://ncbi.nlm.nih.gov/pubmed/24760417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2447-3
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