PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML

The transcription factor PU.1, encoded by the murine Sfpi1 gene (SPI1 in humans), is a member of the Ets transcription factor family and plays a vital role in commitment and maturation of the myeloid and lymphoid lineages. Murine studies directly link primary acute myeloid leukaemia (AML) and decrea...

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Bibliographic Details
Published in:Carcinogenesis
Main Authors: Verbiest, Tom, Bouffler, Simon, Nutt, Stephen L., Badie, Christophe
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392607/
https://ncbi.nlm.nih.gov/pubmed/25750172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgv016
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