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Comparative Laboratory Evolution of Ordered and Disordered Enzymes

Intrinsically disordered proteins are ubiquitous in nature. To assess potential evolutionary advantages and disadvantages of structural disorder under controlled laboratory conditions, we directly compared the evolvability of weakly active ordered and disordered variants of dihydrofolate reductase b...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Schulenburg, Cindy, Stark, Yvonne, Künzle, Matthias, Hilvert, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392238/
https://ncbi.nlm.nih.gov/pubmed/25697360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638080
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