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Comparative Laboratory Evolution of Ordered and Disordered Enzymes
Intrinsically disordered proteins are ubiquitous in nature. To assess potential evolutionary advantages and disadvantages of structural disorder under controlled laboratory conditions, we directly compared the evolvability of weakly active ordered and disordered variants of dihydrofolate reductase b...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4392238/ https://ncbi.nlm.nih.gov/pubmed/25697360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638080 |
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