GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein

Aberrant posttranslational modifications (PTMs) of proteins, namely phosphorylation, induce abnormalities in the biological properties of recipient proteins, underlying neurological diseases including Parkinson's disease (PD). Genome-wide studies link genes encoding α-synuclein (α-Syn) and Tau...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Credle, J J, George, J L, Wills, J, Duka, V, Shah, K, Lee, Y-C, Rodriguez, O, Simkins, T, Winter, M, Moechars, D, Steckler, T, Goudreau, J, Finkelstein, D I, Sidhu, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392080/
https://ncbi.nlm.nih.gov/pubmed/25394490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.179
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