Multiplex Ligation-dependent Probe Amplification Can Clarify HER2 Status in Gastric Cancers with “Polysomy 17”

Therapy with trastuzumab confers a survival benefit in HER2 positive advanced gastric and gastroesophageal adenocarcinoma. HER2 status is evaluated by immunohistochemistry (IHC) and in situ hybridization (ISH). An ISH ratio of HER2 to centromere 17 (CEP17) ≥2.0 is considered amplified. This assumes...

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Vydáno v:J Cancer
Hlavní autoři: Wang, Tao, Amemiya, Yutaka, Henry, Pauline, Seth, Arun, Hanna, Wedad, Hsieh, Eugene T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392047/
https://ncbi.nlm.nih.gov/pubmed/25874002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.11424
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