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Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase.

Protein-tyrosine-phosphatase 2C (PTP2C, also named SHPTP2, SHPTP3, or PTP1D) is a cytosolic enzyme with two Src homology 2 domains. We have investigated its regulation by phosphorylation in PC12 rat pheochromocytoma cells. In untreated cells, PTP2C was phosphorylated predominantly on serine residues...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Peraldi, P, Zhao, Z, Filloux, C, Fischer, E H, Van Obberghen, E
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43918/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8197172/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.11.5002
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